Sodium-glucose co-transporter-2 inhibitor (SGLT2i) may contribute late-aging and longevity


  • Hiroshi Bando Tokushima University / Medical Research, Tokushima, Japan


sodium-glucose co-transporter-2 inhibitors (SGLT2i), Oral hypoglycemic agents (OHAs), left ventricular ejection fraction (LVEF), Hazard ratio (HR) chronic kidney disease (CKD)


Recently, sodium-glucose co-transporter-2 inhibitors (SGLT2i) have been a topic for oral hypoglycemic agents (OHAs) for diabetes. It suggested positive effects on the heart and kidneys from EMPAREG-OUTCOME study, CANVAS program, and DECLARE-TIMI 58 study. SGLT2i are expected to become the useful agents that transcend OHAs, from three recent reports. They are i) Dapagliflozin in Patients with Heart Failure and Reduced Ejection trial (DAPA-HF), ii) the Empagliflozin outcome trial in Patients with chronic heart Failure with Reduced Ejection Fraction trial (EMPEROR-Reduced), and iii) dapagliflozin-chronic kidney disease trial (DAPA-CKD). SGLT2i may become an agent for late-aging and longevity in the future.


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Bando H. Possible sodium-glucose cotransporter-2 (SGLT-2) inhibitors for reducing effects of blood glucose and also blood pressure. Asp Biomed Clin Case Rep. 2020;3(3):186-90. DOI:






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