The use of fenugreek supplementation in diabetes


  • Aamir Jalal Al Mosawi Baghdad Medical City and the Iraqi Ministry of Health, Baghdad, Iraq


Fenugreek, diabetes, research findings


Dietary health supplements have increasingly used in the prevention and treatment of chronic disorders. During the previous decades, fenugreek (Trigonella foenum-graecum) seeds have been reported to have hypoglycemic and cholesterol lowering effects when used in type 1 and type 2 diabetes mellitus patients, and in experimental diabetic animals. The aim of this paper is to review fenugreek research findings relevant to its use in diabetes. There is convincing research evidence suggesting that fenugreek can improve hyperglycemia and has a protective effective against diabetic complications through immunomodulatory, insulin stimulation, and antioxidant effects, enhancing adipocyte differentiation, inhibition of inflammation in adipose tissues, and preventing or lessening pancreatic and renal damage. Many of the beneficial effects of fenugreek in diabetes have been attributed to four bioactive components including diosgenin, 4-hydroxyisoleucine, furostanolic saponins, and the fiber in fenugreek.                           


Mishkinsky JS, Goldschmied A, Joseph B, Ahronson Z, Sulman FG. Hypoglycaemic effect of Trigonella foenum graecum and Lupinus termis (leguminosae) seeds and their major alkaloids in alloxan-diabetic and normal rats. Arch Int Pharmacodyn Ther 1974 Jul; 210(1):27-37. PMID: 4280278.

Ghafghazi T, Sheriat HS, Dastmalchi T, Barnett RC. Antagonism of cadmium and alloxan-induced hyperglycemia in rats by Trigonella foenum graecum. Pahlavi Med J 1977 Jan; 8(1):14-25. PMID: 834467.

Ribes G, Sauvaire Y, Baccou JC, Valette G, Chenon D, Trimble ER, Loubatières-Mariani MM. Effects of fenugreek seeds on endocrine pancreatic secretions in dogs. Ann Nutr Metab 1984; 28(1):37-43. Doi: 10.1159/000176780. PMID: 6703649.

Ribes G, Sauvaire Y, Da Costa C, Baccou JC, Loubatieres-Mariani MM. Antidiabetic effects of subfractions from fenugreek seeds in diabetic dogs. Proc Soc Exp Biol Med 1986 Jun; 182(2):159-66. Doi: 10.3181/00379727-182-42322. PMID: 2871558.

Madar Z, Abel R, Samish S, Arad J. Glucose-lowering effect of fenugreek in non-insulin dependent diabetics. Eur J Clin Nutr 1988 Jan; 42(1):51-4. PMID: 3286242.

Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990 Apr; 44(4):301-6. PMID: 2194788.

Khosla P, Gupta DD, Nagpal RK. Effect of Trigonella foenum graecum (Fenugreek) on blood glucose in normal and diabetic rats. Indian J Physiol Pharmacol 1995 Apr; 39(2):173-4. PMID: 7649611.

Sauvaire Y, Petit P, Broca C, Manteghetti M, Baissac Y, Fernandez-Alvarez J, Gross R, Roye M, Leconte A, Gomis R, Ribes G. 4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion. Diabetes 1998 Feb; 47(2):206-10. Doi: 10.2337/diab. 47.2.206. PMID: 9519714.

Broca C, Gross R, Petit P, Sauvaire Y, Manteghetti M, Tournier M, Masiello P, Gomis R, Ribes G. 4-Hydroxyisoleucine: experimental evidence of its insulinotropic and antidiabetic properties. Am J Physiol 1999 Oct; 277(4):E617-23. Doi: 10.1152/ajpendo.1999.277.4.E617. PMID: 10516120.

Raju J, Gupta D, Rao AR, Yadava PK, Baquer NZ. Trigonella foenum graecum (fenugreek) seed powder improves glucose homeostasis in alloxan diabetic rat tissues by reversing the altered glycolytic, gluconeogenic and lipogenic enzymes. Mol Cell Biochem 2001 Aug; 224(1-2):45-51. Doi: 10.1023/a: 1011974630828. PMID: 116931 99.

Anuradha CV, Ravikumar P. Restoration on tissue antioxidants by fenugreek seeds (Trigonella Foenum Graecum) in alloxan-diabetic rats. Indian J Physiol Pharmacol 2001 Oct; 45(4):408-20. PMID: 11883146.

Gupta A, Gupta R, Lal B. Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study. J Assoc Physicians India 2001 Nov; 49:1057-61. PMID: 11868855.

Puri D, Prabhu KM, Murthy PS. Mechanism of action of a hypoglycemic principle isolated from fenugreek seeds. Indian J Physiol Pharmacol 2002 Oct; 46(4):457-62. PMID: 12683221.

Thakran S, Siddiqui MR, Baquer NZ. Trigonella foenum graecum seed powder protects against histopathological abnormalities in tissues of diabetic rats. Mol Cell Biochem. 2004 Nov; 266(1-2):151-9. Doi: 10.1023/b:mcbi.0000049153.14295.0d. PMID: 15646037.

Xue WL, Li XS, Zhang J, Liu YH, Wang ZL, Zhang RJ. Effect of Trigonella foenum-graecum (fenugreek) extract on blood glucose, blood lipid and hemorheological properties in streptozotocin-induced diabetic rats. Asia Pac J Clin Nutr 2007; 16 Suppl 1:422-6. PMID: 17392143.

Lu FR, Shen L, Qin Y, Gao L, Li H, Dai Y. Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus. Chin J Integr Med 2008 Mar; 14(1):56-60. Doi: 10. 1007/s11655-007-9005-3. PMID: 18219452.

Kassaian N, Azadbakht L, Forghani B, Amini M. Effect of fenugreek seeds on blood glucose and lipid profiles in type 2 diabetic patients. Int J Vitam Nutr Res 2009 Jan; 79(1):34-9. Doi: 10.1024/0300-9831.79.1.34. PMID: 19839001.

Mowla A, Alauddin M, Rahman MA, Ahmed K. Antihyperglycemic effect of Trigonella foenum-graecum (fenugreek) seed extract in alloxan-induced diabetic rats and its use in diabetes mellitus: a brief qualitative phytochemical and acute toxicity test on the extract. Afr J Tradit Complement Altern Med. 2009 May 7; 6(3):255-61. Doi: 10.4314/ajtcam.v6i3.57165. PMID: 20448850.

Hamden K, Masmoudi H, Carreau S, Elfeki A. Immunomodulatory, beta-cell, and neuroprotective actions of fenugreek oil from alloxan-induced diabetes. Immunopharmacol Immunotoxicol 2010 Sep; 32(3):437-45.Doi:10.3109/0892397090 3490486. PMID: 20100065.

Uemura T, Hirai S, Mizoguchi N, et al. Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues. Mol Nutr Food Res 2010 Nov; 54(11):1596-608. Doi: 10.1002/mnfr.200900609. PMID: 20540147.

Xue W, Lei J, Li X, Zhang R. Trigonella foenum graecum seed extract protects kidney function and morphology in diabetic rats via its antioxidant activity. Nutr Res. 2011 Jul; 31(7):555-62. Doi: 10.1016/j.nutres.2011.05.010. PMID: 21840472.

Puri D, Prabhu KM, Murthy PS. Antidiabetic Effect of GII Compound Purified from Fenugreek (Trigonella foenum graecum Linn) Seeds in Diabetic Rabbits. Indian J Clin Biochem 2012 Jan; 27(1):21-7. Doi: 10.1007/s12291-011-0151-1.PMID: 23277708.

Hamza N, Berke B, Cheze C, et al. Preventive and curative effect of Trigonella foenum-graecum L. seeds in C57BL/6J models of type 2 diabetes induced by high-fat diet. J Ethnopharmacol 2012 Jul 13; 142(2):516-22. Doi: 10.1016/j.jep.2012.05.028. PMID: 22633967.

Gupta SK, Kumar B, Nag TC, Srinivasan BP, Srivastava S, Gaur S, Saxena R. Effects of Trigonella foenum-graecum (L.) on retinal oxidative stress, and proinflammatory and angiogenic molecular biomarkers in streptozotocin-induced diabetic rats. Mol Cell Biochem 2014 Mar; 388(1-2):1-9. Doi: 10.1007/s11010-013-1893-2. PMID: 24242137.

Neelakantan N, Narayanan M, de Souza RJ, van Dam RM. Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials. Nutr J 2014 Jan 18; 13:7. Doi: 10.1186/1475-2891-13-7. PMID: 24438170.

Smith JD, Clinard VB. Natural products for the management of type 2 diabetes mellitus and comorbid conditions. J Am Pharm Assoc (2003) 2014 Sep-Oct; 54(5):e304-18; quiz e319-21. Doi: 10.1331/JAPhA.2014.14537. PMID: 251073 89.

Rawat AK, Korthikunta V, Gautam S, Pal S, Tadigoppula N, Tamrakar AK, Srivastava AK. 4-Hydroxyisoleucine improves insulin resistance by promoting mitochondrial biogenesis and act through AMPK and Akt dependent pathway. Fitoterapia 2014 Dec; 99:307-17. Doi:10.1016/j.fitote.2014.10.006. PMID: 25454462.

Gaddam A, Galla C, Thummisetti S, Marikanty RK, Palanisamy UD, Rao PV. Role of Fenugreek in the prevention of type 2 diabetes mellitus in prediabetes. J Diabetes Metab Disord 2015 Oct 2; 14:74. Doi: 10.1186/s40200-015-0208-4. PMID: 26436069.

Verma N, Usman K, Patel N, et al. A multicenter clinical study to determine the efficacy of a novel fenugreek seed (Trigonella foenum-graecum) extract (Fenfuro™) in patients with type 2 diabetes. Food Nutr Res 2016 Oct 11; 60:32382.Doi:10. 3402/ fnr.v60.32382. PMID: 27733237.

Geberemeskel GA, Debebe YG, Nguse NA. Antidiabetic Effect of Fenugreek Seed Powder Solution (Trigonella foenum-graecum L.) on Hyperlipidemia in Diabetic Patients. J Diabetes Res 2019 Sep 5; 2019:8507453. Doi:10.1155/2019/8507453. PMID: 31583253.

Hadi A, Arab A, Hajianfar H, et al. The effect of fenugreek seed supplementation on serum irisin levels, blood pressure, and liver and kidney function in patients with type 2 diabetes mellitus: A parallel randomized clinical trial. Complement Ther Med 2020 Mar; 49:102315. Doi: 10.1016/j.ctim.2020.102315. PMID: 32147060.






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